IL12RB1 anticorps (AA 624-662)

N° du produit ABIN5647871

Cet anticorps anti-IL12RB1 est un anticorps Lapin Polyclonal détectant IL12RB1 dans WB. Adapté pour Humain.

Aperçu rapide pour IL12RB1 anticorps (AA 624-662) (ABIN5647871)

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL12RB1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IL12RB1 anticorps

Épitope: AA 624-662

Purification: Antigen affinity purified

Immunogène: Amino acids 624-662 (DKGERTEPLEKTELPEGAPELALDTELSLEDGDRCKAKM-human) were used as the immunogen for the IL12RB1 / CD212 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CD212 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the CD212 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur IL12RB1

Antigène: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Autre désignation: IL12RB1 / CD212

Sujet: IL12RB1, mapped to 19p13.11, is also known as CD212. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. And this protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

UniProt: P42701

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation